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Identification of Repressor Element 1 in Secretin/PACAP/VIP Genes
Author(s) -
LEE LEO T.O.,
LEE VIEN H.Y.,
YUAN PAULA Y.,
CHOW BILLY K.C.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.050
Subject(s) - repressor , gene silencing , gene , transcription factor , biology , secretin , transcription (linguistics) , genetics , regulatory sequence , microbiology and biotechnology , secretion , endocrinology , linguistics , philosophy
Repressor element 1 (RE‐1) is a negative, cis ‐acting regulatory element that interacts with the transcription factor RE‐1‐silencing transcription factor (REST). REST represses gene expression by two repressor domains that recruit other factors including mSin3 and CoREST. RE‐1 has been identified in an increasing number of neuronal‐specific genes, and recently, functional REST sites have also been discovered in VIP and PACAP genes. In the present article, we demonstrated for the first time that RE‐1 sites are present in the 5′ flanking regions of several secretin/PACAP/VIP genes by in silico analysis. This observation suggests that RE‐1/REST is a common negative regulatory pathway of this peptide family.