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Localization of Small Heterodimer Partner (SHP) and Secretin in Mouse Duodenal Cells
Author(s) -
LAM IAN P.Y.,
LEE LEO T.O.,
CHOI H.S.,
CHOW BILLY K.C.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.047
Subject(s) - neurod , secretin , transcription factor , promoter , microbiology and biotechnology , small heterodimer partner , biology , medicine , gene , chemistry , cancer research , gene expression , endocrinology , pancreas , biochemistry , nuclear receptor
Previous studies have demonstrated the transcriptional repressive property of the atypical nuclear receptor, small heterodimer partner (SHP), on NeuroD. NeuroD is a basic helix‐loop‐helix transcription factor that has also been shown to be important in modulating secretin gene expression. The present study revealed the activation of the human secretin core promotor by overexpressing NeuroD, and the localization of SHP and secretin‐producing cells in mouse duodenal epithelium by immunohistochemical stainings. These results indicated that SHP and secretin are potentially co‐expressed and lead us to propose a novel regulatory pathway, in which SHP represses NeuroD's positive regulatory activity on secretin gene.