Clues to VIP Function from Knockout Mice | Zendy

HAMIDI S.A. | Zendy; SZEMA A.M. | Zendy; LYUBSKY S. | Zendy; DICKMAN K.G. | Zendy; DEGENE A. | Zendy; MATHEW S.M. | Zendy; WASCHEK J.A. | Zendy; SAID S.I. | Zendy

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Clues to VIP Function from Knockout Mice

Author(s) -

HAMIDI S.A.,

SZEMA A.M.,

LYUBSKY S.,

DICKMAN K.G.,

DEGENE A.,

MATHEW S.M.,

WASCHEK J.A.,

SAID S.I.

Publication year - 2006

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1317.035

Subject(s) - vasoactive intestinal peptide , methacholine , knockout mouse , bronchial hyperresponsiveness , medicine , septic shock , inflammation , immunology , asthma , shock (circulatory) , airway , endocrinology , lung , respiratory disease , sepsis , neuropeptide , anesthesia , receptor

We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: ( a ) airway reactivity and airway inflammation, as indicators of bronchial asthma; ( b ) mortality from endotoxemia, a model of septic shock; and ( c ) the pulmonary circulation. VIP KO mice showed: ( a ) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; ( b ) a greater susceptibility to death from endotoxemia; and ( c ) evidence suggestive of pulmonary hypertension.

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