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Clues to VIP Function from Knockout Mice
Author(s) -
HAMIDI S.A.,
SZEMA A.M.,
LYUBSKY S.,
DICKMAN K.G.,
DEGENE A.,
MATHEW S.M.,
WASCHEK J.A.,
SAID S.I.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.035
Subject(s) - vasoactive intestinal peptide , methacholine , knockout mouse , bronchial hyperresponsiveness , medicine , septic shock , inflammation , immunology , asthma , shock (circulatory) , airway , endocrinology , lung , respiratory disease , sepsis , neuropeptide , anesthesia , receptor
We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: ( a ) airway reactivity and airway inflammation, as indicators of bronchial asthma; ( b ) mortality from endotoxemia, a model of septic shock; and ( c ) the pulmonary circulation. VIP KO mice showed: ( a ) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; ( b ) a greater susceptibility to death from endotoxemia; and ( c ) evidence suggestive of pulmonary hypertension.