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Modulation of Pituitary Adenylate Cyclase‐Activating Polypeptide (PACAP) Expression in Explant‐Cultured Guinea Pig Cardiac Neurons
Author(s) -
GIRARD BEATRICE M.,
YOUNG BETH A.,
BUTTOLPH THOMAS R.,
WHITE SHERYL L.,
PARSONS RODNEY L.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.030
Subject(s) - adenylate kinase , guinea pig , explant culture , pituitary adenylate cyclase activating peptide , medicine , endocrinology , cyclase , neurotrophic factors , biology , chemistry , vasoactive intestinal peptide , microbiology and biotechnology , in vitro , neuropeptide , receptor , biochemistry , stimulation
Pituitary adenylate cyclase‐activating polypeptide (PACAP) expression was quantified in explant‐cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP‐immunoreactive neurons and pro‐PACAP transcript levels increased significantly. Treatment with neurturin or glial‐derived neurotrophic factor significantly suppressed the percentage of PACAP‐IR neurons, but not pro‐PACAP transcript levels.