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The Glucagon‐Like Peptides
Author(s) -
BRUBAKER PATRICIA L.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.006
Subject(s) - assimilation (phonology) , ingestion , gastrointestinal tract , glucagon like peptide 1 , homeostasis , digestion (alchemy) , glucagon like peptide 2 , pancreas , nutrient sensing , nutrient , glucagon , glucose homeostasis , intestinal epithelium , chemistry , biology , endocrinology , medicine , epithelium , biochemistry , peptide , insulin , signal transduction , diabetes mellitus , insulin resistance , philosophy , genetics , chromatography , linguistics , organic chemistry , type 2 diabetes
The glucagon‐like peptides, GLP‐1 and GLP‐2, are cosecreted by intestinal L cells in response to nutrient ingestion. These peptides exert multiple effects on the gastrointestinal tract and pancreas to regulate the digestion, absorption, and assimilation of ingested nutrients, as well as providing feedback signals to the brain to modulate food intake. Tropic effects of GLP‐1 and GLP‐2 on their major peripheral target tissues, the beta cell and the intestinal epithelium, respectively, further enhance capacity for nutrient handling. When taken together, these findings demonstrate the diverse actions of the intestinal glucagon‐like peptides to regulate nutrient homeostasis.