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Methamphetamine and Brain Histamine: A Study Using Histamine‐Related Gene Knockout Mice
Author(s) -
IWABUCHI KENTARO,
KUBOTA YASUHIKO,
ITO CHIHIRO,
WATANABE TAKESHI,
WATANABE TAKEHIKO,
YANAI KAZUHIKO
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1316.016
Subject(s) - histaminergic , histamine , histidine decarboxylase , methamphetamine , meth , histamine h1 receptor , histamine h3 receptor , inhibitory postsynaptic potential , pharmacology , knockout mouse , chemistry , receptor , histamine h2 receptor , neurochemical , biology , endocrinology , histidine , biochemistry , antagonist , amino acid , organic chemistry , monomer , acrylate , polymer
A bstract : The central histamine (HA) neurons that originate from the posterior hypothalamus modulate a variety of physiological functions. In order to investigate the roles of brain histaminergic neuron system in the behavioral effects of methamphetamine (METH), we administrated METH repeatedly to l‐histidine decarboxylase (HDC)‐, histamine H1 receptor‐, H2 receptor‐gene knockout (KO) mice, H1/H2 receptor‐gene double KO mice, and wild type (WT) mice corresponding to each of them, and we measured locomotor activities. We also measured the contents of monoamines and amino acids in the brain of HDC‐gene KO and WT mice after a single administration of METH. METH‐induced locomotor hyperactivity and the development of behavioral sensitization were facilitated more in the HDC‐gene KO mice and H1/H2 gene double KO mice than the WT mice, suggesting that brain histamine has an inhibitory effect on the METH action through both H1 and H2 receptors. In addition, neurochemical study suggested the involvement of the GABAergic neuron system in the inhibitory effect of brain histamine.