Premium
No Association Is Found between the Candidate Genes of t‐PA/Plasminogen System and Japanese Methamphetamine‐Related Disorder: A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse
Author(s) -
IWATA N,
INADA T,
HARANO M,
KOMIYAMA T,
YAMADA M,
SEKINE Y,
IYO M,
SORA I,
UJIKE H,
OZAKI N
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1316.004
Subject(s) - substance abuse , genetics , methamphetamine , association (psychology) , medicine , psychiatry , psychology , biology , psychotherapist
A bstract : In the central nervous system, tissue‐plasminogen activator (t‐PA)/plasmin system is involved in long‐term synaptic plasticity and remodeling, and participates in rewarding effects of methamphetamine (MAP), by acutely regulating MAP‐induced dopamine release in the nucleus accumbens. The aim of this study was to examine the relationships between the patients with MAP abusers/psychosis and the t‐PA/plasminogen system genes. Subjects comprised 185 MAP abusers and 288 healthy controls. Four polymorphisms in the t‐PA, plasminogen activator inhibitor, and plasminogen genes were examined in the present study. No significant differences were observed in each polymorphism between healthy controls and MAP abusers/psychosis. This study suggests that t‐PA/plasminogen system is unlikely to be a major contributor to the substance abuse liability and/or the development of MAP psychosis.