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Structure and Function of Glutamate Receptors
Author(s) -
MAYER MARK
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1315.020
Subject(s) - glutamate receptor , neuroscience , receptor , gating , excitatory postsynaptic potential , ion channel , metabotropic glutamate receptor , neurotransmission , metabotropic glutamate receptor 2 , ion channel linked receptors , chemistry , molecular neuroscience , metabotropic glutamate receptor 6 , spinal cord , biology , biophysics , biochemistry
A bstract : Understanding how glutamate receptors, a group of molecules that mediate information between neurons in the brain, work at the molecular level has been the focus of my research. The key role of glutamate receptors is to mediate excitatory synaptic transmission throughout the brain and spinal cord. To understand the mechanisms by which this occurs requires a molecular understanding of the receptor proteins. Our experimental approach required breaking down the receptor into smaller assemblies that are easier to work with. We ended up, after a few years, with the first molecular model for how ion channel gating occurs.