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Neuroanatomical Changes Associated with Pharmacotherapy in Posttraumatic Stress Disorder
Author(s) -
BREMNER J DOUGLAS,
VERMETTEN ERIC
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1314.012
Subject(s) - paroxetine , hippocampal formation , hippocampus , posttraumatic stress , neurogenesis , psychology , serotonin reuptake inhibitor , neuroscience , cognition , pharmacotherapy , reuptake inhibitor , medicine , clinical psychology , psychiatry , antidepressant
A bstract : Brain imaging studies have mapped out the neural circuitry of posttraumatic stress disorder (PTSD), implicating brain areas sensitive to stress such as the hippocampus. Animal studies show that antidepressants promote hippocampal neurogenesis and block the effects of stress on the hippocampus. We found that treatment of PTSD patients for a year with the serotonin reuptake inhibitor (SSRI) paroxetine resulted in a 5% increase in hippocampal volume and a 35% improvement in verbal declarative memory function. Patients subjectively reported an improvement in cognition and work performance. These studies are consistent with the idea that antidepressants have a beneficial effect on hippocampal function in PTSD patients.