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Human and Nonhuman Primate Lentiviral Infection and Autoimmunity
Author(s) -
ONLAMOON NATTAWAT,
PATTANAPANYASAT KOVIT,
ANSARI AFTAB A.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1313.091
Subject(s) - nonhuman primate , autoimmunity , virology , primate , immunology , biology , medicine , neuroscience , immune system , evolutionary biology
A bstract : The goal of this communication is to summarize the following—the types of autoimmune responses that have been characterized in human HIV‐1 infection; the potential mechanisms that were initially thought to be the basis for such autoimmune responses; the prevalence and incidence of conventional autoimmune diseases with HIV‐1 infection; the spectrum of autoimmune disorders following the institution of HAART and its associated mechanisms; the role of such autoimmunity in SIV‐infected nonhuman primates; and the molecular basis for autoimmune responses, such as the role of exosomes in lentiviral disease.