Premium
A Deiminated Viral Peptide to Detect Antibodies in Rheumatoid Arthritis
Author(s) -
MERLINI GIUSEPPINA,
ANZILOTTI CONSUELO,
CHIMENTI DANIELE,
TOMMASI CRISTINA,
BOMBARDIERI STEFANO,
MIGLIORINI PAOLA
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1313.025
Subject(s) - rheumatoid arthritis , antibody , immunology , medicine , rheumatoid factor , arthritis , peptide , biology , biochemistry
A bstract : The data presented suggest that a deiminated viral peptide is specifically recognized by antibodies contained in rheumatoid arthritis (RA) sera. Antipeptide antibodies are not associated with the presence or severity of specific manifestations of RA, but are more frequent in subjects with erosive arthritis. Taking into account the association with rheumatoid factor and with erosive arthritis, we can conclude that antipeptide antibodies are markers of severe forms of RA. Our data also show familial aggregation of anticitrullinated peptide antibodies.