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Histo‐Blood Group Antigens as Allo‐ and Autoantigens
Author(s) -
NYDEGGER URS E.,
TEVAEARAI HENDRIK,
BERDAT PASCAL,
RIEBEN ROBERT,
CARREL THIERRY,
MOHACSI PAUL,
FLEGEL WILLY A.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1313.006
Subject(s) - abo blood group system , alloimmunity , transplantation , transfusion medicine , immunology , autoimmune hemolytic anemia , agglutination (biology) , human leukocyte antigen , genotyping , antigen , isoantigens , medicine , blood group antigens , blood type (non human) , isoantibodies , monoclonal antibody , rh blood group system , blood transfusion , biology , antibody , genetics , genotype , gene
A bstract : The science of blood groups has made giant steps forward during the last decade. Blood‐group typing of red blood cells (RBCs) is performed on more than 15 million samples per year in Europe, today much less often for forensic reasons than for clinical purposes such as transfusion and organ transplantation. Specific monoclonal antibodies are used with interpretation on the basis of RBC agglutination patterns, and mass genotyping may well be on its way to becoming a routine procedure. The discovery that most blood group systems, whose antigens are by definition found on RBCs, are also expressed in multiple other tissues has sparked the interest of transplantation medicine in immunohematology beyond the HLA system. The one and only “histo‐blood group” (HBG) system that is routinely considered in transplantation medicine is ABO, because ABO antigen‐incompatible donor/recipient constellations are preferably avoided. However, other HBG systems may also play a role, thus far underestimated. This paper is an up‐to‐date analysis of the importance of HBG systems in the alloimmunity of transplantation and autoimmune events, such as hemolytic anemia.