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Gamma‐Delta T Cells as Orally Induced Suppressor Cells in Rats: In Vitro Characterization
Author(s) -
WILDNER GERHILD,
THURAU STEPHAN R.,
DIEDRICHSMÖHRING MARIA
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.050
Subject(s) - in vitro , cd8 , in vivo , major histocompatibility complex , immunology , adoptive cell transfer , mimotope , autoimmunity , biology , chemistry , microbiology and biotechnology , antigen , cytotoxic t cell , immune system , epitope , biochemistry , genetics
A bstract : Gamma‐delta T cells from orally tolerized rats adoptively transfer suppression of experimental autoimmune uveitis. In vivo and in vitro these regulatory cells specifically recognize retinal autoantigen peptide PDSAg and its mimotope B27PD, but not other mimicry peptides. Proliferation of γ/δ T cells was MHC class II and CD8 dependent.