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IL‐18 and Antigen‐Specific CD4 + Regulatory T Cells in Peyer's Patches
Author(s) -
TSUJI NORIKO M.,
NOWAK BERNADETA
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.049
Subject(s) - antigen , homeostasis , immunity , immunology , microbiology and biotechnology , peyer's patch , microfold cell , biology , chemistry , immune system
A bstract : A study using gene‐deficient mice revealed that IL‐18 is essential for inducing antigen‐specific regulatory T cells and oral tolerance. It is also suggested that IL‐18 is a functional downregulator for immunogenic dendritic cells, contributing to the maintenance of homeostasis for intestinal immunity.