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The Thymus Plays a Role in Oral Tolerance Induction in Experimental Autoimmune Encephalomyelitis
Author(s) -
SONG FEI,
GIENAPP INGRID E.,
SHAWLER TODD,
GUAN ZHEN,
WHITACRE CAROLINE C.
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.047
Subject(s) - experimental autoimmune encephalomyelitis , immunology , encephalomyelitis , oral tolerance , medicine , neuroscience , multiple sclerosis , biology , immune system
A bstract : Mice are protected from experimental autoimmune encephalomyelitis (EAE) when fed myelin basic protein (MBP). Thymectomized mice do not exhibit oral tolerance. We found evidence for two mechanisms to explain the role of the thymus in oral tolerance: a site for deletion of autoreactive T cells and a source of regulatory T cells.