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Early Events in Antigen‐Specific Regulatory T Cell Induction via Nasal and Oral Mucosa
Author(s) -
SAMSOM JANNEKE N.,
HAUETBROERE FEMKE,
UNGER WENDY W. J.,
BERKEL LISETTE A.,
KRAAL GEORG
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.045
Subject(s) - immune system , antigen , immunology , mucous membrane of nose , cytokine , acquired immune system , oral mucosa , medicine , biology , pathology
A bstract : Mucosal Tr prevent harmful immune responses to innocuous antigens that are encountered at the mucosae. This unique subset of Tr is adaptive, antigen specific, and suppresses irrespective of cytokine polarization. Here we study the earliest events of mucosal Tr induction and factors that control their differentiation from naive T cells.