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Transforming Growth Factor‐β Regulates Susceptibility of Epithelial Apoptosis in Murine Model of Colitis
Author(s) -
SAKURABA HIROTAKE,
ISHIGURO YOH,
YAMAGATA KAZUFUMI,
TAGAWA YOHICHI,
IWAKURA YOICHIRO,
SEKIKAWA KENJI,
MUNAKATA AKIHIRO,
NAKANE AKIO
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.044
Subject(s) - apoptosis , colitis , transforming growth factor , cancer research , microbiology and biotechnology , chemistry , biology , immunology , biochemistry
A bstract : Transforming growth factor (TGF)‐beta has a key role in intestinal homeostasis. Our present data suggest that TGF‐beta, which was constitutively expressed by lamina propria mononuclear cells and epithelium, affected epithelial cells. Abnormal suppression of TGF‐beta could enhance the sensitivity of epithelial cells to apoptosis associated with interferon‐gamma in DSS‐induced colitis.