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CD45 Knockout Mice, Diet, and Colitis: In the Absence of CD45, Colitis Follows Dietary Changes
Author(s) -
LÓPEZA MARÍA C.,
HOLMES NICK
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.041
Subject(s) - colitis , knockout mouse , chemistry , medicine , receptor
A bstract : Healthy CD45 KO mice show a Th2‐type cytokine secretion profile in their small intestines. Dietary supplementation with human infant formula induced colitis and a shift toward a Th1‐type profile, suggesting that diet can alter cytokine secretion.