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Macrophage Migration Inhibitory Factor and Activator Protein‐1 in Ulcerative Colitis
Author(s) -
ISHIGURO YOH,
YAMAGATA KAZUFUMI,
SAKURABA HIROTAKE,
MUNAKATA AKIHIRO,
NAKANE AKIO,
MORITA TAKAYUKI,
NISHIHIRA JUN
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.040
Subject(s) - macrophage migration inhibitory factor , ulcerative colitis , activator (genetics) , cytokine , glucocorticoid , immunology , inhibitory postsynaptic potential , colitis , medicine , cancer research , disease , receptor
A bstract : Macrophage migration inhibitory factor (MIF) is a cytokine that has potent antisteroid effects. We determined that MIF is involved in the glucocorticoid‐resistant inflammatory process of ulcerative colitis (UC), and the altered AP‐1 signal is a potent therapeutic target for refractory UC.