Macrophage Migration Inhibitory Factor and Activator Protein‐1 in Ulcerative Colitis | Zendy

ISHIGURO YOH | Zendy; YAMAGATA KAZUFUMI | Zendy; SAKURABA HIROTAKE | Zendy; MUNAKATA AKIHIRO | Zendy; NAKANE AKIO | Zendy; MORITA TAKAYUKI | Zendy; NISHIHIRA JUN | Zendy

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Macrophage Migration Inhibitory Factor and Activator Protein‐1 in Ulcerative Colitis

Author(s) -

ISHIGURO YOH,

YAMAGATA KAZUFUMI,

SAKURABA HIROTAKE,

MUNAKATA AKIHIRO,

NAKANE AKIO,

MORITA TAKAYUKI,

NISHIHIRA JUN

Publication year - 2004

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1309.040

Subject(s) - macrophage migration inhibitory factor , ulcerative colitis , activator (genetics) , cytokine , glucocorticoid , immunology , inhibitory postsynaptic potential , colitis , medicine , cancer research , disease , receptor

A bstract : Macrophage migration inhibitory factor (MIF) is a cytokine that has potent antisteroid effects. We determined that MIF is involved in the glucocorticoid‐resistant inflammatory process of ulcerative colitis (UC), and the altered AP‐1 signal is a potent therapeutic target for refractory UC.

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