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Differential Immune Induction with Subcutaneous versus Oral Administration of a Diabetogenic Insulin Peptide in the NOD Mouse
Author(s) -
DEVENDRA DEVASENAN,
PARONEN JOHANNA,
LIU EDWIN,
MORIYAMA HIROAKI,
MIAO DONGMEI,
YU LIPING,
EISENBARTH GEORGE S.
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.039
Subject(s) - nod , epitope , nod mice , insulin , autoantibody , immune system , subcutaneous injection , peptide , endocrinology , oral administration , medicine , antigen , diabetes mellitus , immunology , antibody , biology , biochemistry
A bstract : The B chain insulin peptide 9 to 23 (B:9–23) is a dominant T cell epitope of the NOD mouse. Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration.