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Comparative study of Oral versus Subcutaneous B:9–23 insulin peptide in Balb/c mice as an experimental model for Autoimmune Diabetes
Author(s) -
DEVENDRA DEVASENAN,
PARONEN JOHANNA,
LIU EDWIN,
MORIYAMA HIROAKI,
TAYLOR ROBERT,
MIAO DONGMEI,
YU LIPING,
EISENBARTH GEORGE
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.038
Subject(s) - insulin , autoantibody , diabetes mellitus , immune system , subcutaneous injection , endocrinology , medicine , peptide , islet , oral administration , immunology , antibody , chemistry , biochemistry
A bstract : Insulin peptide B:9–23 (amino acids 9 to 23 of the B chain) can induce immune targeting of insulin and islets in normal Balb/c mice. The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin.