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Early Upregulation of T Cell IL‐10 Production Plays an Important Role in Oral Tolerance Induction
Author(s) -
CONG Y,
LIU C,
WEAVER C T,
ELSON C O
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.037
Subject(s) - downregulation and upregulation , oral tolerance , adoptive cell transfer , microbiology and biotechnology , immunology , t cell , chemistry , biology , immune system , biochemistry , gene
A bstract : Early in oral tolerance induction, IL‐10‐producing CD4 + T cells were increased, and adoptive transfer of IL‐10‐deficient CD4 + T cells failed induction of oral tolerance, suggesting a key role of IL‐10 production in such a process.
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