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Immune Regulation in the Intestine: A Balancing Act between Effector and Regulatory T Cell Responses
Author(s) -
POWRIE FIONA
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.030
Subject(s) - effector , immune system , microbiology and biotechnology , regulatory t cell , biology , chemistry , immunology , t cell , il 2 receptor
A bstract : The immune system in the intestine must respond rapidly to invading pathogens without mounting sustained effector cell responses to the indigenous commensal bacteria. Results from this laboratory using the T cell transfer model of colitis suggest that specialized populations of regulatory T cells control the immune response in the intestine. Regulatory T (Tr) cell activity is enriched within the naturally arising CD4 + CD25 + Tr subset that has been shown to prevent a number of inflammatory diseases. CD4 + CD25 + Tr cells control intestinal inflammation induced by both innate and adaptive immune responses via IL‐10‐ and TGF‐β‐dependent mechanisms. Recent results have shown that CD4 + CD25 + Tr cells can cure established colitis, suggesting their utility for the treatment of inflammatory bowel disease.