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Selective Generation of Gut‐Tropic T Cells in Gut‐Associated Lymphoid Tissues: Requirement for GALT Dendritic Cells and Adjuvant
Author(s) -
SVENSSON MARCUS,
JOHANSSONLINDBOM BENGT,
WURBEL MARCANDRÉ,
MALISSEN BERNARD,
MÁRQUEZ GABRIEL,
AGACE WILLIAM
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.025
Subject(s) - gut associated lymphoid tissue , adjuvant , lymphatic system , biology , microbiology and biotechnology , immunology , follicular dendritic cells , chemistry , antigen presenting cell , immune system , t cell
A bstract : To gain entry into peripheral tissues, effector T lymphocytes express specific combinations of adhesion molecules and chemokine receptors. Expression of these are induced during activation in regional secondary lymphoid organs. Herein, we describe a role for GALT DCs in the generation of CCR9 + α 4 β 7 + gut tropic lymphocytes.