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Commonly Used Drugs Impair Oral Tolerance in Mice
Author(s) -
PECQUET SOPHIE,
PRIOULT GUÉNOLÉE,
CAMPBELL JOHN,
GERMAN BRUCE,
TURINI MARCO
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.021
Subject(s) - medicine , oral tolerance , ibuprofen , antibiotics , drug tolerance , pharmacology , oral administration , biology , microbiology and biotechnology
A bstract : Ibuprofen and antibiotics are commonly prescribed during early childhood. When given to mice at the time at which oral tolerance is induced, both treatments affect either the induction or the maintenance of oral tolerance. These results suggest that the coadministration of these and similarly acting drugs should be considered cautiously for infants at risk of allergy.