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The Presentation of Haptenated Proteins and Activation of T Cells in the Mesenteric Lymph Nodes by Dendritic Cells in the TNBS Colitis Rat
Author(s) -
ISHIGURO YOH,
SAKURABA HIROTAKE,
YAMAGATA KAZUFUMI,
MUNAKATA AKIHIRO
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.017
Subject(s) - mesenteric lymph nodes , lymph , immune system , antigen presentation , dendritic cell , antigen presenting cell , colitis , immunology , antigen , chemistry , cross presentation , t cell , microbiology and biotechnology , medicine , biology , pathology
A bstract : We described the role of dendritic cells (DCs) in aspects of T cell activation at the mesenteric lymph nodes (MLN) in trinitrobenzene sulfonic acid (TNBS)‐induced colitis. An antigenic‐immune response is induced at the MLN, and dendritic cells are the affected cell type. Cross‐linking and GRO/CINC‐1 have synergistic effects for DC maturation.