CCL25 Enhances CD103‐Mediated Lymphocyte Adhesion to E‐Cadherin | Zendy

ERICSSON ANNA | Zendy; ARYA ANU | Zendy; AGACE WILLIAM | Zendy

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CCL25 Enhances CD103‐Mediated Lymphocyte Adhesion to E‐Cadherin

Author(s) -

ERICSSON ANNA,

ARYA ANU,

AGACE WILLIAM

Publication year - 2004

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1309.014

Subject(s) - ccl25 , chemokine , adhesion , cadherin , downregulation and upregulation , chemistry , microbiology and biotechnology , immunology , lymphocyte , cd8 , intestinal epithelium , epithelium , biology , chemokine receptor , immune system , medicine , cell , pathology , biochemistry , gene , organic chemistry

A bstract : Our results demonstrate that (1) CD103 is upregulated on CD8 + T cells subsequent to their entry into the small intestinal epithelium, and (2) that the chemokine CCL25 enhances CD103‐mediated adhesion to E‐cadherin. These results suggest a novel role for chemokines in modulating interactions between lymphocytes and epithelial cells at mucosal surfaces.

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