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CCL25 Enhances CD103‐Mediated Lymphocyte Adhesion to E‐Cadherin
Author(s) -
ERICSSON ANNA,
ARYA ANU,
AGACE WILLIAM
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.014
Subject(s) - ccl25 , chemokine , adhesion , cadherin , downregulation and upregulation , chemistry , microbiology and biotechnology , immunology , lymphocyte , cd8 , intestinal epithelium , epithelium , biology , chemokine receptor , immune system , medicine , cell , pathology , biochemistry , gene , organic chemistry
A bstract : Our results demonstrate that (1) CD103 is upregulated on CD8 + T cells subsequent to their entry into the small intestinal epithelium, and (2) that the chemokine CCL25 enhances CD103‐mediated adhesion to E‐cadherin. These results suggest a novel role for chemokines in modulating interactions between lymphocytes and epithelial cells at mucosal surfaces.