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Uptake of Antigens from the Intestine by Dendritic Cells
Author(s) -
MacPHERSON GORDON,
MILLING SIMON,
YRLID ULF,
COUSINS LESLEY,
TURNBULL EMMA,
HUANG FANGPING
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.010
Subject(s) - lamina propria , antigen , immune system , immunology , small intestine , context (archaeology) , microbiology and biotechnology , biology , dendritic cell , antigen presenting cell , t cell , epithelium , endocrinology , paleontology , genetics
A bstract : The intestinal immune system responds to ingested antigens in a variety of ways, ranging from tolerance to full immunity. How T cells are instructed to make these differential responses is still unclear. Dendritic cells (DCs) sample enteric antigens in the lamina propria and Peyer's patches, and transport them within the patch or to mesenteric nodes where they are presented to lymphocytes. It is probable that DCs also transmit information that influences the outcome of T cell activation, but the nature of this information and the factors in the intestine that regulate DC behavior and properties are far from clear. We have developed a model in the rat that permits analysis of DCs actually in the process of migration from the intestine to mesenteric nodes. In this paper we will review those aspects of our research that relate to antigen uptake and discuss these in the context of other experimental systems.