Activation of a Unique Population of CD8 +  T Cells by Intestinal Epithelial Cells | Zendy

ALLEZ MATTHIEU | Zendy; BRIMNES JENS | Zendy; SHAO LING | Zendy; DOTAN IRIS | Zendy; NAKAZAWA ATSUSHI | Zendy; MAYER LLOYD | Zendy

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Activation of a Unique Population of CD8 + T Cells by Intestinal Epithelial Cells

Author(s) -

ALLEZ MATTHIEU,

BRIMNES JENS,

SHAO LING,

DOTAN IRIS,

NAKAZAWA ATSUSHI,

MAYER LLOYD

Publication year - 2004

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1309.004

Subject(s) - immune system , antigen , cd8 , cd1d , microbiology and biotechnology , immunology , biology , population , intestinal mucosa , inflammatory bowel disease , subfamily , chemistry , natural killer t cell , disease , medicine , pathology , gene , genetics , environmental health

A bstract : Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8 + T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member (gp180) and CD1d. This subset, which is regulatory in vitro , may play a role in the control of intestinal immune responses toward luminal antigens. A lack of expansion of these CD8 + regulatory T cells, probably related to the defective expression of the gp180/CD1d complex, is observed in inflammatory bowel disease.

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