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Activation of a Unique Population of CD8 + T Cells by Intestinal Epithelial Cells
Author(s) -
ALLEZ MATTHIEU,
BRIMNES JENS,
SHAO LING,
DOTAN IRIS,
NAKAZAWA ATSUSHI,
MAYER LLOYD
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1309.004
Subject(s) - immune system , antigen , cd8 , cd1d , microbiology and biotechnology , immunology , biology , population , intestinal mucosa , inflammatory bowel disease , subfamily , chemistry , natural killer t cell , disease , medicine , pathology , gene , genetics , environmental health
A bstract : Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8 + T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member (gp180) and CD1d. This subset, which is regulatory in vitro , may play a role in the control of intestinal immune responses toward luminal antigens. A lack of expansion of these CD8 + regulatory T cells, probably related to the defective expression of the gp180/CD1d complex, is observed in inflammatory bowel disease.