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Premium The Role of Iron in the Pathogenesis of Experimental Allergic Encephalomyelitis and Multiple Sclerosis
Publication year2004
Publication title
annals of the new york academy of sciences
Resource typeJournals
PublisherBlackwell Publishing Ltd
A bstract : Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are autoimmune disorders resulting in demyelination in the central nervous system (CNS). Pathologically, the blood‐brain barrier becomes damaged, macrophages and T cells enter into the CNS, oligodendrocytes and myelin are destroyed, astrocytes and microglia undergo gliosis, and axons become transected. Data from several biochemical and pharmacological studies indicate that free radicals participate in the pathogenesis of EAE, and iron has been implicated as the catalyst leading to their formation. The primary focus of this article is the examination of the role of iron in the pathogenesis of MS and EAE. Particular attention will be paid to the role and distribution of iron and proteins involved with iron metabolism (e.g., transferrin, ferritin, heme oxygenase‐1, etc.) in normal and disease states of myelin. Furthermore, therapeutic interventions aimed at iron, iron‐binding proteins, and substrates or products of iron‐catalyzed reactions leading to free radical production will be discussed.
Subject(s)biochemistry , biology , central nervous system , chemistry , encephalomyelitis , experimental autoimmune encephalomyelitis , ferritin , gliosis , immunology , inflammation , medicine , microglia , multiple sclerosis , myelin , neuroscience , pathogenesis , pathology , transferrin
SCImago Journal Rank1.712

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