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Association Between I 2 Binding Sites and Monoamine Oxidase‐B Activity in Platelets
Author(s) -
ZHU H,
PILETZ JE
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1304.044
Subject(s) - platelet , monoamine oxidase , monoamine oxidase b , chemistry , association (psychology) , biochemistry , medicine , enzyme , psychology , psychotherapist
A bstract : An I 2 imidazoline binding site on monoamine oxidase‐B (MAO‐B) is known to be encoded by a noncatalytic part of the enzyme, different from that which recognizes mechanism‐based inhibitors. Herein, the relationship between I 2 ‐imidazoline binding sites and MAO‐B activity has been assessed using a semi‐purified source of MAO‐B: platelet mitochondrial membranes. A positive correlation between I 2 sites and MAO‐B activity was observed (r 5 0.61, P 5 0.0016) among 24 human subjects. Nevertheless, the variance in MAO‐B activity cannot be completely accounted for in relation to I 2 sites. Therefore, I 2 density and MAO‐B activity are only weakly correlated in platelets.