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Effect of Agmatine on the Time Course of Brain Inflammatory Cytokines After Injury in Rat Pups
Author(s) -
FENG YANGZHENG,
LeBLANC MICHAEL H.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1304.017
Subject(s) - agmatine , tumor necrosis factor alpha , proinflammatory cytokine , medicine , interleukin 1β , cytokine , pharmacology , endocrinology , anesthesia , interleukin , inflammation , chemistry , enzyme , biochemistry , putrescine
A bstract : Pro‐inflammatory cytokines play an important role in brain injury. Agmatine reduces brain injury. Does agmatine act by reducing cytokines? Seven‐day‐old rat pups had the right carotid artery ligated and then were subjected to 2.5 hours of 8% oxygen. Agmatine (100 mg/kg) or vehicle was administered at 5 minutes after reoxygenation. Cytokines were measured in the cortex by enzyme‐linked immunosorbent assay. Interleukin (IL)‐6, IL‐1 b , and tumor necrosis factor‐alpha (TNF‐ a ) were significantly increased after reoxygenation. Agmatine had no effect.