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Agmatine‐Morphine Interaction on Nociception in Mice
Author(s) -
RUIZDURÁNTEZ EDUARDO,
LLORENTE JAVIER,
ULIBARRI ISABEL,
PINEDA JOSEBA,
UGEDO LUISA
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1304.013
Subject(s) - agmatine , morphine , nitric oxide , long term potentiation , nociception , pharmacology , chemistry , tail flick test , anesthesia , medicine , biochemistry , receptor , arginine , organic chemistry , amino acid
A bstract : The aim of this study was to investigate the possible participation of nitric oxide in the agmatine‐mediated potentiation of morphine‐induced analgesia in mice. Agmatine and L‐NAME (a nitric oxide synthesis inhibitor) enhanced morphine‐induced analgesia in the tail flick test, but not in the hot plate test. L‐NAME did not block the agmatine‐induced potentiation of morphine effect. Our results indicate that agmatine potentiates morphine‐induced spinal but not supraspinal analgesia, and that this effect is not mediated by a nitric oxide‐dependent mechanism.