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Genetic Factors in Cardiac Hypertrophy
Author(s) -
DORN GERALD W.,
HAHN HARVEY S.
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1302.019
Subject(s) - pressure overload , muscle hypertrophy , decompensation , cardiac hypertrophy , heart failure , medicine , cardiology , myocardial hypertrophy , cardiac decompensation , endocrinology
A bstract : Cardiac hypertrophy is an adaptive response to any cardiac insult or stress that increases hemodynamic load. Cardiac hypertrophy can exist in a state of compensation or progress to a decompensated state (i.e., heart failure) over time. It has been established through transgenic overexpression and gene ablation studies that multiple signaling pathways are involved in the induction of hypertrophy as well as its decompensation. This article reviews the role of Gaq in the development of pressure overload hypertrophy and discusses the relationships between Gαq and β‐adrenergic receptors, RGS proteins, and the proapoptotic factor, Nix/Bnip3L.