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Linking Gene Expression to Function: Metabolic Flexibility in the Normal and Diseased Heart
Author(s) -
TAEGTMEYER HEINRICH,
GOLFMAN LEONARD,
SHARMA SAUMYA,
RAZEGHI PETER,
ARSDALL MELISSA
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1302.017
Subject(s) - function (biology) , flexibility (engineering) , gene expression , expression (computer science) , computational biology , biology , gene , microbiology and biotechnology , genetics , computer science , mathematics , statistics , programming language
A bstract : Metabolism transfers energy from substrates to ATP. As a “metabolic omnivore,” the normal heart adapts to changes in the environment by switching from one substrate to another. We propose that this flexibility is lost in the maladapted, diseased heart. Both adaptation and maladaptation are the results of metabolic signals that regulate transcription of key cardiac regulatory genes. We propose that metabolic remodeling precedes, initiates, and sustains functional and structural remodeling. The process of metabolic remodeling then becomes a target for pharmacological intervention restoring metabolic flexibility and normal contractile function of the heart.