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Obstetric Complications Correlate with Neurobehavioral and Brain Structural Alterations in Young Relatives at Risk for Schizophrenia
Author(s) -
GILBERT ANDREW R.,
MONTROSE DEBRA M.,
SAHNI SARAH D.,
DIWADKAR VAIBHAV A.,
KESHAVAN MATCHERI S.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1301.030
Subject(s) - schizophrenia (object oriented programming) , offspring , psychopathology , risk factor , psychiatry , magnetic resonance imaging , medicine , pregnancy , psychology , genetics , biology , radiology
A bstract : As complications of pregnancy and birth may be important risk factors for the development of schizophrenia, studying the “roots” of schizophrenia in high‐risk offspring may better elucidate the interface between biology, environment, and susceptibility to illness. Using magnetic resonance imaging (MRI), neurobehavioral assessments and obstetric histories, we found several significant correlations between these multiple factors, suggesting that birth complications may be a nonspecific etiopathogenic risk factor for psychopathology in young relatives at risk for schizophrenia.