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Glutamatergic Animal Models of Schizophrenia
Author(s) -
MOGHADDAM BITA,
JACKSON MARK E.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1300.065
Subject(s) - schizophrenia (object oriented programming) , glutamatergic , neuroscience , nmda receptor , glutamate receptor , neurotransmission , psychosis , psychology , medicine , psychiatry , biology , receptor , genetics
A bstract : Several lines of evidence, including recent genetic linkage studies implicating susceptibility genes for schizophrenia, make a strong case that abnormal NMDA receptor‐mediated neurotransmission is a major locus for the pathophysiology of schizophrenia. Animal models that are relevant to putative NMDA dysfunction in schizophrenia have excellent face validity for several symptoms of schizophrenia and are important tools for the design of novel pharmacological intervention in schizophrenia. The present chapter includes a brief review of the utility of these models and the search for new medications that have the potential of normalizing glutamate neurotransmission in schizophrenia.