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Evaluating Glutamatergic Transmission in Schizophrenia
Author(s) -
TAMMINGA CAROL A.,
LAHTI ADRIENNE C.,
MEDOFF DEBORAH R.,
GAO XUEMIN,
HOLCOMB HENRY H.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1300.062
Subject(s) - glutamatergic , schizophrenia (object oriented programming) , neuroscience , glutamate receptor , human brain , psychology , ketamine , psychiatry , pharmacology , medicine , receptor
A bstract : Our findings with schizophrenia and the glutamate system have relied on the characterization of the clinical response of patients to ketamine and their functional brain imaging response (rCBF) to the drug. Prior to the human studies reported here, we had evaluated the region activation characteristics and pharmacology of PCP and its congener MK 801 in animals. What I will report in this paper has been individually reported elsewhere but brought together here in a new synthesis.