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Clinical Studies Implementing Glutamate Neurotransmission in Mood Disorders
Author(s) -
SANACORA GERARD,
ROTHMAN DOUGLAS L.,
MASON GRAEME,
KRYSTAL JOHN H.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1300.018
Subject(s) - neurotransmitter systems , neurotransmitter , neurotransmission , neuroscience , glutamate receptor , mood disorders , mood , neurotransmitter agents , pathophysiology , brain function , psychology , medicine , pharmacology , psychiatry , central nervous system , receptor , dopamine , anxiety
A bstract : Emerging evidence suggests that the amino acid neurotransmitter systems are associated with the pathophysiology and treatment of mood disorders. Recent advances in the areas of molecular neurobiology, pharmacology, and magnetic resonance spectroscopy (MRS) now provide better tools to probe the function of the amino acid neurotransmitter systems and are affording us the opportunity to better investigate the relationship of these systems to mood disorders. Here we review the available literature in the field and suggest a possible pathophysiological model that may account for the many of the findings.