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Apoptosis in Prostate Carcinoma before and after Neoadjuvant Therapy with LH‐RH Analog
Author(s) -
BENCINI STEFANIA,
MIGALDI MARIO,
CASTAGNETTI GIOVANNI,
PINCELLI CARLO,
FERRARI PAOLO,
GAETANI CARMELA,
TRENTINI GIAN PAOLO
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.142
Subject(s) - survivin , apoptosis , prostate cancer , prostate , prostate carcinoma , oncology , cancer research , medicine , cancer , chemistry , biochemistry
A bstract : This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH‐RH analog, demonstrating that this therapy induced high AI and bax and survivin overexpression, thus acting as a proapoptotic agent in prostate cancer. A statistically significant correlation was found between high AI and overexpression of bax protein after therapy. It is probable that this kind of therapy is deeply implicated in promoting the apoptotic intrinsic pathway.