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Inhibition of CDKs: A Strategy for Preventing Kainic Acid‐Induced Apoptosis in Neurons
Author(s) -
VERDAGUER E,
JORDÀ ELVIRA G.,
STRANGES ALESSANDRA,
CANUDAS ANNA M.,
JIMÉNEZ ANDRÉS,
SUREDA FRANCESC X.,
PALLÀS MERCÈ,
CAMINS ANTONI
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.122
Subject(s) - kainic acid , kainate receptor , ionotropic effect , ampa receptor , neuroprotection , cyclin dependent kinase , glutamate receptor , microbiology and biotechnology , apoptosis , chemistry , neuroscience , stimulation , receptor , neurodegeneration , pharmacology , biology , cell cycle , biochemistry , disease , medicine
A bstract : Stimulation of ionotropic glutamate receptors are implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Recently this has been demonstrated in the expression of cell cycle proteins in vulnerable neurons in Alzheimer's disease. Thus, the aim of the present study was to evaluate the expression of cell cycle proteins in cerebellar granule cells after stimulation of AMPA/KA receptors and likewise to study the neuroprotective effects of CDK inhibitors. Our results demonstrated that after a treatment with CDK inhibitors, a significant decrease in apoptotic nuclei induced by kainic acid was found in the presence of flavopiridol and 3‐ATA. We concluded that CDK activation is involved, at least, in part, in the pro‐apoptotic effects of kainic acid.