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Neuronal Death versus Synaptic Pathology in Alzheimer's Disease
Author(s) -
BERTONIFREDDARI CARLO,
FATTORETTI PATRIZIA,
SOLAZZI MORENO,
GIORGETTI BELINDA,
STEFANO GIUSEPPINA,
CASOLI TIZIANA,
MEIERRUGE WILLIAM
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.116
Subject(s) - hippocampus , neuroscience , synapse , cerebellum , disease , alzheimer's disease , central nervous system , biology , dementia , neuron , pathology , medicine , psychology
A bstract : Neuron and synapse numeric densities as well as the average size and surface density of the synaptic junctional areas were measured in the hippocampus and cerebellum of adult, old, and demented (Alzheimer's disease) patients. Our findings support the notion that synaptic loss represents per se a prominent and early damage affecting zones of the central nervous system reported to show a different vulnerability to age‐ and pathology‐related changes.