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Apoptosis Inversely Correlates with Rabies Virus Neurotropism
Author(s) -
THOULOUZE MARIAISABEL,
LAFAGE MIREILLE,
YUSTE VICTOR J.,
KROEMER GUIDO,
SUSIN SANTOS A.,
ISRAEL NICOLE,
LAFON MONIQUE
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.112
Subject(s) - jurkat cells , neurotropic virus , rabies virus , apoptosis , virology , rabies , biology , virus , caspase , microbiology and biotechnology , immunology , programmed cell death , t cell , genetics , immune system
A bstract : We report that non‐neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase‐dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat‐vect), but also a caspase‐independent pathway. Cell redistribution of the apoptosis‐inducing factor (AIF) was observed in Jurkat‐vect infected with RV vaccine strain. Bcl‐2 overproduction in Jurkat T cells (Jurkat‐Bcl‐2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. The inverse correlation of the induction of apoptosis and the capacity of a virus strain to invade the brain suggests that blockage of apoptosis could be a strategy selected by neurotropic virus to favor its progression through the nervous system.