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Cytochrome c , Glutathione, and the Possible Role of Redox Potentials in Apoptosis
Author(s) -
HANCOCK JOHN T.,
DESIKAN RADHIKA,
NEILL STEVEN J.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.081
Subject(s) - redox , cytochrome c , glutathione , chemistry , cytochrome , apoptosis , oxidation reduction , cytochrome b , biophysics , biochemistry , microbiology and biotechnology , biology , inorganic chemistry , enzyme , gene , mitochondrial dna
A bstract : The redox environment of the cell is now thought to be extremely important to control the activity of many proteins. During apoptosis, the intracellular redox potential (E h ) becomes more positive, with possible consequences for the mechanisms of apoptosis. Glutathione and cytochrome c might both influence and be influenced by the cellular redox environment and therefore be important in the progression of apoptosis.