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Early Activation and Induction of Apoptosis in T Cells Is Independent of c‐Fos
Author(s) -
BIERBAUM HANNA,
BAUMANN SVEN,
HERR INGRID,
TUCKERMANN JAN P.,
HESS JOCHEN,
SCHORPPKISTNER MARINA,
ANGEL PETER
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.040
Subject(s) - apoptosis , dexamethasone , c fos , glucocorticoid , thymocyte , spleen , microbiology and biotechnology , chemistry , biology , endocrinology , t cell , immunology , gene expression , gene , immune system , biochemistry
A bstract : We used c‐Fos‐deficient activated T cells from the spleen and c‐Fos‐deficient thymocytes to address the capacity of these cells to undergo apoptosis in response to various stimuli. To determine the role of c‐Fos in apoptosis regulation in thymocytes, we challenged thymocytes from wild‐type and c‐Fos‐deficient mice with either TPA or the glucocorticoid dexamethasone. After various time points cells were stained according to the Nicoletti method and analyzed by FACS. Thymocytes from both genotypes exhibited similar efficiency of apoptosis in response to treatment with TPA or dexamethasone. Our data provide clear evidence that c‐Fos is not required for apoptosis regulation in activated T cells as well as in thymocytes.