Premium
Involvement of the Change in Chromatin Structure in Thymocyte Apoptosis Induced by Phosphorylation of Histones
Author(s) -
ENOMOTO RIYO,
YOSHIDA YUKARI,
KOMAI TOMOE,
SUGAHARA CHIYOKO,
YASUOKA YUKA,
LEE EIBAI
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.038
Subject(s) - chromatin , histone , dna fragmentation , thymocyte , okadaic acid , phosphorylation , apoptosis , fragmentation (computing) , chemistry , microbiology and biotechnology , phosphatase , dna , apoptotic dna fragmentation , biology , biochemistry , programmed cell death , genetics , antigen , ecology , cd8
A bstract : The inhibitors of protein phosphatase such as calyculin A and okadaic acid induced thymocyte apoptosis. DNA fragmentation was increased in the nuclei from thymocytes treated with calyculin A, which accelerated phosphorylation of histones. Judging from the circular dichroism analysis, the structure of soluble chromatin was changed by the treatment with calyculin A. These results suggest that the change in chromatin structure may be one of the molecular mechanisms of internucleosomal DNA fragmentation.