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Orphan Nuclear Receptor Nur77 Translocates to Mitochondria in the Early Phase of Apoptosis Induced by Synthetic Chenodeoxycholic Acid Derivatives in Human Stomach Cancer Cell Line SNU‐1
Author(s) -
JEONG JIN HEE,
PARK JOOSUNG,
MOON BONGKYUNG,
KIM MIN CHAN,
KIM JAEKON,
LEE SUNGEUN,
SUH HONGSUK,
KIM NAM DEUK,
KIM JONGMIN,
PARK YOUNG CHUL,
YOO YOUNG HYUN
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.029
Subject(s) - apoptosis , nerve growth factor ib , mitochondrion , dna fragmentation , nuclear receptor , chemistry , cancer cell , fragmentation (computing) , cell culture , cancer research , microbiology and biotechnology , cancer , programmed cell death , biology , biochemistry , genetics , ecology , transcription factor , gene
A bstract : Apoptosis‐inducing activity of synthetic CDCA derivatives, HS‐1199 and HS‐1200, on gastric cancer cell line SNU‐1 cells was explored. CDCA derivatives demonstrated various apoptosis hallmarks, such as mitochondrial changes, activation of caspase, DNA fragmentation, and nuclear condensation. Importantly, the orphan receptor Nur77 (TR3) was shown to translocate from the nucleus to mitochondria at the early time points after CDCA derivatives treatment. These data support the theory that CDCA derivatives‐induced apoptosis of SNU‐1 gastric cancer cell lines is mediated by mitochondria and caspase, and, at least in part, by Nur77.