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TNFα Potentiates 2‐Methoxyestradiol‐Induced Mitochondrial Death Pathway
Author(s) -
DJAVAHERIMERGNY MOJGAN,
WIETZERBIN JUANA,
ROUILLARD DANY,
BESANÇON FRANÇOISE
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.026
Subject(s) - tumor necrosis factor alpha , apoptosis , programmed cell death , cancer research , microbiology and biotechnology , sarcoma , necrosis , signal transduction , transcription factor , mitochondrion , chemistry , biology , medicine , immunology , pathology , gene , biochemistry
A bstract : Ewing sarcoma cells are resistant to TNFα‐induced cell death and this resistance results from the activation of the transcription factor NF‐κB. Here, we investigated whether NF‐κB activation interferes with 2‐Me‐induced cell death signaling in Ewing sarcoma cells and we examined the effect of treatment of these cells with 2‐Me either alone or in combination with TNFα. Our results show that TNFa cooperates with 2‐Me to induce apoptosis in Ewing tumor cells through mitochondrial cell death signaling. These results suggest that the use of TNFα in combination with 2‐Me may be beneficial for Ewing tumor treatment.