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Apolipoprotein E Genotype and Age at Menopause
Author(s) -
KOOCHMESHGI JALAL,
MEHDI HOSSEINIMAZINANI SEYED,
MORTEZA SEIFATI SEYED,
HOSEINPURNOBARI NASRIN,
TEIMOORITOOLABI LADAN
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.105
Subject(s) - menopause , apolipoprotein e , genotype , allele , demography , medicine , gerontology , biology , genetics , disease , gene , sociology
A bstract : We tested the hypothesis that there is a connection between apolipoprotein E ( APOE ) genotype and age at menopause. A sample of women aged between 50 and 60 years who had reached natural menopause was studied. Survival analysis of data showed a significant relationship between APOE genotype and age at menopause, carriers of the APOE 4 allele reaching menopause at an earlier age. Our findings can have a bearing on the question of the evolution of this major human polymorphism and human life history. These findings are also relevant to the question of the connection between reproductive parameters and age‐associated diseases.