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Early‐Life Programming of Aging and Longevity: The Idea of High Initial Damage Load (the HIDL Hypothesis)
Author(s) -
GAVRILOV LEONID A.,
GAVRILOVA NATALIA S.
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.091
Subject(s) - longevity , life span , postponement , gerontology , accelerated aging , biology , medicine , operations management , engineering , reliability engineering
A bstract : In this study, we test the predictions of the high initial damage load (HIDL) hypothesis, a scientific idea that early development of living organisms produces an exceptionally high load of initial damage, which is comparable with the amount of subsequent aging‐related deterioration accumulating during the rest of the entire adult life. This hypothesis predicts that even small progress in optimizing the early‐developmental processes can potentially result in a remarkable prevention of many diseases in later life, postponement of aging‐related morbidity and mortality, and significant extension of healthy life span.